Prevention of infection at drying-off by stimulation of mammary gland immunity

Develop a biological response modifier that will promote a sustained immunity of the mammary teat and protect the gland from invading pathogens.


  • Chitosan is a molecule derived from the shell structure of crustaceans and shellfish and significantly increased the number of immune cells in the udder and levels of compounds associated with involution, while stimulating local immune response during dry-off period.
  • The chitosan hydrogel function is not affected by the teat sealant when used together. In addition, the use of a chitosan-based hydrogel in combination with teat sealant may combine the benefits of stimulating the immune response while generating a physical barrier between the teat and outside environment.
  • A hydrogel made up of chitosan can be used in combination with existing mastitis-preventing tools during dry off. This method could potentially decrease prophylactic antibiotics while decreasing the risk of developing new mastitis infections during the dry-off period.

Research Team

  • Pierre Lacasse (Principal Investigator, Sherbrooke RDC – AAFC)
  • Samuel Lanctôt (MSc candidate, UMcGill)
  • Xin Zhao (collaborator, UMcGill)
  • Patrick Fustier (collaborator, CRDA-AAFC) Not in photo